309pdoes Administration Order of Sequential Fec- Docetaxel as Adjuvant Chemotherapy for Breast Cancer Affect on the Toxicities? : a Retrospective Analysis from a Single-center.

Aim: Anthracyclines and taxanes based regimens have been established as one of standard adjuvant chemotherapy for early breast cancer. For the high-risk patients, sequential rather than the concomitant use of both agents should be considered. Conventionally, Anthracyclines followed by taxanes (AT) are preferred. However, some recent trials reported that preceding taxanes had equivalent efficacy. Since each has different toxic profile, it is important to compare AT with TA in terms of toxicity and relative dose intensity (RDI). The purpose of this retrospective study was to assess the influence of administration order.